There are many contents of peptide labeling and peptide modification, commonly used are N-terminal labeling or modification, N-terminal fluorescein, photosensitizer, N-terminal fatty acid, C-terminal labeling or modification, phosphorylation, disulfide cyclization, lysine modification, high amino-acid modification, PEG modification, single and double labeling, azide modification, Mal modification, N-Me modification, coupling and so on. It is widely used in the research of polypeptide drugs, polypeptide biology, polypeptide antibodies and polypeptide reagents. At present, it is widely used in non-radionuclide labeling (C13, H2, N15), fluorescent labeling (FAM, FITC, etc.), biological labeling, phosphorylation modification, etc. The specific situation can be WeChat, email, Whatsapp consultation:
| Detailed classification: | |
| C-terminal labeling technique | Amidation,C-termainal |
| Aldehydes | |
| Alcohols | |
| pNA (p-Nitroanilide) | |
| AMC | |
| AFC | |
| Cysteamide | |
| Ester | |
| N-Alkyl Amides | |
| N-terminal labeling technique | Acetylated |
| Palmytolyl | |
| HYNIC | |
| Biotinylated | |
| Bromoacetylated | |
| DOTA，DTPA conjugated | |
| Formylated | |
| Tetradecyl, octadecyl （Myristoylated） | |
| Succinylation, palmitization, apple acidification, lipid acidification, etc.（N-Succinylated） | |
| Fluorescent labeling modification | C-terminal modification: AFC,AMC,Dap(Dnp),Lys(Dye),pNA, Rh110 |
| terminal modification: Bodipy-FL, Cy3, Cy5, Texas Red, 5-Tamra, 5-lodoacetamido fluorescein Rhodamine 110 and Rhodamine B Luciferin, EDANS FAM, FITC, MCA, Rox, Sulforhodamine 101, 5-TAMRA | |
| Cyclization reaction | End to end ring, middle ring, special ring （N -> C or Head to Tail） |
| 2 Disulfide,3 Disulfide (Disulfide(S-S bond formation).Trisulfide formation) | |
| Natural product active peptides (Cyclic-natural peptides) | |
| Methylation modification | Side chain methylation Lys (For), Lys (Me), Lys (Me) 2, Lys (Me) 3, Arg (Me) 2 symmetrical, D-Tyr (Me), D-Tyr (Et) |
| N-terminal methylation(N-Me-Arg,N-Me-Asp,N-Me-Glu, N-Me-Leu,N-Me-Nle,N-Me-Nva,N-Me-Phe,N-Me-S N-Me-Ser, N-Me-Trp,N-Me-Thr,N-Me-Val） | |
| Several special modifications | Various coupling(BSA, KLH conjugated peptides for antibody production) |
| Phosphorylation(Phosphoserine,Phosphothreonine,Phosphotyrosine) | |
| Sulfonation （Sulfated Tyrosine or Serine） | |
| MAPS (Multiple Antigenic Peptide) | |
| Glycopeptides | |
| PEGylation | |
Greatpeptide company provides a variety of modifications, the following is part of the modification price list, for reference only, according to the difficulty of the sequence to give the corresponding discount, the specific situation can be whatsApp, email, WeChat consultation.
5 mg | 10mg | 20 mg | |
| N-terminal modifications | |||
| N-Acetylation( Free ) | Free | Free | Free |
| N-Formylated | Free | Free | Free |
| N-Myristoylated | ￥200 | ￥300 | ￥400 |
| N-Succinylated | ￥200 | ￥300 | ￥400 |
| N-Biotinlytion | ￥300 | ￥500 | ￥800 |
| N-terminal Fatty acid | ￥200 | ￥300 | ￥500 |
| N-Rhodamine B | ￥400 | ￥500 | ￥800 |
| N-FITC, 5-FAM,6-FAM | ￥400 | ￥600 | ￥800 |
| N-Bromoacetylated | ￥500 | ￥800 | ￥1000 |
| N-Alkyl Amides | ￥500 | ￥800 | ￥1000 |
| DOTA, DTPA, Hynic conjugated | ￥800 | ￥1200 | ￥1600 |
| N-BODIPY,Cy3,Cy5 | quotation request | quotation request | quotation request |
| C-terminal modifications | |||
| C-Amidation | Free | Free | Free |
| C-Aldehydes | ￥800 | ￥1200 | ￥1500 |
| C-Alcohols | ￥800 | ￥1200 | ￥1500 |
| C-Chloromethyl Ketones | ￥800 | ￥1200 | ￥1500 |